Sanofi's genetic disorder drug shows mixed results in late-stage trials

By Bhanvi Satija

LONDON, Feb 2 (Reuters) - French drugmaker Sanofi said on Monday that its experimental genetic disorder treatment showed promise in a late-stage study of patients with ​a type of Gaucher disease, but failed to meet the main goal in ‌a separate trial.

The oral drug, venglustat, was being tested in patients with Fabry disease and type 3 Gaucher disease. Both ‌inherited conditions are caused by enzyme deficiencies that lead to the accumulation of toxic substances in the body.

Previous failures in trials of patients with Parkinson's disease and a type of acute kidney disease have prompted Sanofi to prioritize testing the drug in rare genetic disorders, where its mechanism of ⁠blocking the buildup of harmful fatty ‌molecules has yielded promising early-stage results.

Analysts have not projected future sales for venglustat as market expectations for its success remain low.

Sanofi is banking on ‍its late-stage pipeline and recent acquisitions to help drive sales growth in the next decade, after the top-selling eczema and asthma drug Dupixent it shares with Regeneron loses exclusivity.

Sanofi's bet could pay off if venglustat is ​eventually approved, making it the first such drug to target neurological symptoms and giving patients ‌an oral dosing option.

"A daily pill could make a serious difference for Gaucher patients facing neurological challenges," said Sanofi research chief Houman Ashrafian.

But the drug's path to regulatory approval looks murky, especially for Fabry disease. Ashrafian said data from the Fabry disease study was still being analysed, while the company said it would work with global regulators to determine next steps.

STUDY DETAILS

The drug ⁠showed superior improvements in neurological symptoms such as speech ​and limb coordination for type 3 Gaucher disease patients, ​compared to those who received enzyme replacement therapy. It also demonstrated statistically significant improvements on three of four secondary goals of that study.

In patients with Fabry ‍disease, venglustat helped reduce ⁠neuropathic and abdominal pain, but not enough to declare statistical success. Sanofi suggested that may be due to a large placebo effect. The company said it helped reduce levels ⁠of plasma lyso-GL-3 in patients, which is an indicator of accumulated harmful fat molecules.

Sanofi already sells Fabrazyme, an enzyme‑replacement ‌therapy for Fabry disease, and markets Cerezyme and the oral drug Cerdelga for ‌Gaucher disease.

(Reporting by Bhanvi SatijaEditing by Bill Berkrot)

Sanofi's genetic disorder drug shows mixed results in late-stage trials

By Bhanvi Satija LONDON, Feb 2 (Reuters) - French drugmaker Sanofi said on Monday that its experimental genetic ...
Factbox-Which are the main parties in Thailand's election and what are their policies?

Feb 2 (Reuters) - Thailand is holding a general election on February 8 with three parties expected to dominate the contest to decide which will lead the Southeast Asian country's next government.

Following are details and key policy pledges of the main parties running in the election.

BHUMJAITHAI PARTY

Led by incumbent Prime Minister Anutin Charnvirakul, Bhumjaithai formed the last government in September after moving in swiftly ​to dismantle the Pheu Thai-led coalition following a court's sacking of then premier Paetongtarn Shinawatra. Bhumjaithai was not a contender in the 2023 and 2019 elections, taking 71 and 51 seats respectively, though enough ‌to earn spots in the coalition governments.

Bhumjaithai has brought in technocrats and will hope to benefit from its incumbency and defections from other parties to boost its share of the vote. It will likely need to form an alliance to lead the next government.

Key policies:

- Phase two ‌of a co-payment subsidy scheme that in stage one covered half of the cost of selected food and consumer goods

- Boost growth to above 3% through a "10-Plus Plan", including support for low-income earners, better income and care for seniors; community-based products; free education with job pathways, support for small businesses

- Construct border walls to prevent smuggling of illicit goods, illegal labour, proliferation of "grey" businesses

- Introduce volunteer soldiers posts with monthly salaries; create 100,000 jobs in a "One Village, One Volunteer Nurse" scheme

- Barter trade for major state purchases such as fighter jets and submarines, paid for with Thai farm goods

- National disaster fund to support co-pay insurance for 29.5 million households

- Cheap loans for buying electric motorcycles

- Boost small businesses through state procurement, ⁠cheap loans, credit guarantees, new market access

- Promote green economy initiatives, community solar cells, ‌and cap household electricity bills

PHEU THAI PARTY

Pheu Thai and its predecessors have dominated Thai politics for the past quarter-century through huge electoral war chests and populist policies that won massive working class support and loyalty.

Founded by divisive, currently jailed billionaire Thaksin Shinawatra, the party has powerful enemies in the royalist establishment. Six premiers from or allied with the Shinawatra ‍family have been removed by military coups and court rulings.

The 2023 election was the first since 2001 where Thaksin-backed parties did not win the most votes. Pheu Thai's support has been challenged of late following Paetongtarn's removal and its failure to fully implement its signature "digital wallet" handout programme.

Key policies:

- "Millionaire-maker" campaign that award nine daily prizes of 1 million baht ($31,556) each, targeting tax filers, seniors over 60, farmers, volunteers and buyers of goods and services

- Top-up incomes for those with annual earnings below 36,000 baht ($1,163)

- For rice, ​cassava, rubber and corn, set market price targets; guarantee farmers at least 30% profit in first year

- Coupons for up to 250 kg (551 pounds) of fertiliser and 150 kg of seeds per household

- Suspend principal and interest ‌for three years on loans up to 500,000 baht for farmers

- Convert land documents to full land title deeds for 33 million rai (about 13 acres)

- 500,000 baht ($16,150) in seed funding per startup, plus five‑year tax exemptions

- Add mental health services as a core benefit under a 30 baht universal healthcare scheme

- Establish a national credit guarantee agency to support small businesses

- Programme aimed at developing 20 million high‑skilled workers

- Affordable housing with low instalments and no downpayment for qualified first-time buyers

- Flat 20 baht rate for all trips on electric trains; two‑year motorcycle tax exemption for delivery riders

- Relief for holders of non-performing loans below specified thresholds; small loans from state banks to repay informal debt

PEOPLE'S PARTY

People's Party is the third incarnation of the progressive movement after its two popular predecessors were dissolved by courts, including Move Forward, which won most votes in the 2023 election but was blocked from forming a government by a Senate ⁠hand-picked by the military.

Surveys consistently show People's Party is Thailand's most popular party, suggesting it still has strong backing among young ​and urban Thais for its liberal policies and institutional reform agenda.

Though it is a contender to win, its efforts to form a government ​could again encounter turbulence, with long-term reforms it has previously pledged and some of its current manifesto posing a challenge to the interests of conservatives, powerful families and business groups with far-reaching political influence.

Key policies:

- Replace military conscription with a fully voluntary military with enlistment contracts of 4-8 years; reduce number of generals; improve welfare for lower-ranking soldiers

- Government guarantees on new ‍loans for small businesses and upgrades to national credit database

- ⁠Tighten screening for company registrations to tackle illicit businesses; crackdown on nominee structures and grey capital; increase penalties and shorten court processes

- Develop a southern port link system to cut logistics costs and strengthen southern economy

- Single transport ticket capping trip prices on urban rail, buses and ferries

- National single-wage formula adjusted annually based on living costs and economic conditions

- Provide 1,000 baht co-payment top-up for 12 million people

- Subsidise ⁠training for new skills; provide courses linked to labour market needs

- Raise VAT to 8% by 2028 and 10% by 2030, with compensation for low‑income households

- Reform to police to prevent buying/selling of police positions

- Limit working hours to five days or 40 hours per week, ‌with overtime pay required beyond

- Implement menstrual leave up to 3 days per month and annual compassionate/care leave up to 15 days

- Establish a 10 billion baht annual fund to buy and ‌absorb surplus farm produce before prices fall

($1 = 31.6900 baht)

(Compiled by Orathai Sriring and Martin Petty; Editing by Raju Gopalakrishnan)

Factbox-Which are the main parties in Thailand's election and what are their policies?

Feb 2 (Reuters) - Thailand is holding a general election on February 8 with three parties expected to dominate the contes...
Japan PM Takaichi's party poised for landslide victory, poll shows

By Leika Kihara

Reuters

TOKYO, Feb 2 (Reuters) - Japanese Prime Minister Sanae Takaichi's party is likely to score a landslide victory in next week's lower house election, a survey by the Asahi newspaper showed, heightening the chance the country will continue to pursue big ​spending and tax cuts.

A strong showing in Sunday's election would solidify Takaichi's grip on her party and give a mandate for her ‌expansionary fiscal policy, which could heighten concerns about Japan's finances and push bond yields higher.

"Implementing expansionary fiscal policy at a time the economy is at near full employment would heighten inflationary ‌pressure" and weaken the yen, said Ryutaro Kono, chief Japan economist at BNP Paribas.

"The Bank of Japan may be forced to accelerate the pace of interest rate hikes to combat the weak yen and inflationary pressures from expansionary fiscal policy," he said.

Takaichi's Liberal Democratic Party is likely to well exceed a majority of 233 seats out of 465 seats up for grabs in the lower house, according to Asahi's poll released on Sunday. That would be an increase from 198 seats ⁠now.

Together with LDP's coalition partner, the Japan Innovation ‌Party or Ishin, the ruling alliance will likely reach 300 seats, the poll showed.

The largest opposition party, the Centrist Reform Alliance, is struggling and could lose half its 167 seats, the Asahi said.

Super-long Japanese government bond yields, which are sensitive to ‍fiscal risks, rose on Monday as investors priced in the chance Takaichi will push through her "proactive" fiscal policy focused on bigger spending and tax cuts.

The yen wobbled after Takaichi's weekend comments in which she talked up the benefits of a weaker currency were seen as condoning its declines and running counter to efforts by Japanese authorities to ​prop it up.

"People say the weak yen is bad right now, but for export industries, it's a major opportunity," Takaichi said on Saturday, adding ‌that the currency's decline would boost the value of Japan's huge foreign reserves.

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A government spokesperson said on Monday Takaichi was not highlighting the benefits of a weak yen, and instead stressing the need to create an economic structure resilient to currency fluctuations.

A weak yen has been a source of headache for Japanese policymakers as it pushes up import costs and broader inflation.

FISCAL RISK WORRIES MAY BE OVERBLOWN

Takaichi's ruling coalition currently holds a slim majority in the powerful lower house but has a minority in the upper house. The premier dissolved parliament last month and called a snap election on February 8 seeking ⁠a mandate for her push to reflate the economy with expansionary fiscal policy.

Japan suffered ​a broad market rout last month after Takaichi pledged to suspend an 8% levy on ​food sales for two years, reviving investor concerns about fiscal discipline in a country with public debt more than twice the size of its economy.

Most parties have also called for a suspension or a cut to the consumption tax to cushion ‍the blow to households from rising living ⁠costs.

Some analysts say a strong LDP win could actually prevent Japan from resorting to extreme tax cuts or spending plans proposed by some opposition parties.

The LDP remains vague on how soon the tax suspension could be put in place, saying only that the timing should be ⁠decided in a meeting of ruling and opposition parties.

In its campaign pledge, the LDP clearly commits to reducing Japan's debt-to-GDP ratio, and pursuing expenditure and revenue reforms, said Takeshi Yamaguchi, ‌chief Japan economist at Morgan Stanley MUFG Securities.

"Our view that excessive concern over Japan's fiscal position is unnecessary remains unchanged," he ‌said.

(Reporting by Leika Kihara; Editing by Cynthia Osterman, Sonali Paul and Stephen Coates)

Japan PM Takaichi's party poised for landslide victory, poll shows

By Leika Kihara TOKYO, Feb 2 (Reuters) - Japanese Prime Minister Sanae Takaichi's party is likely to score...
Alibaba to spend $431 million for Lunar New Year AI push as chatbot war heats up

BEIJING, Feb 2 (Reuters) - Alibaba said on Monday it will spend 3 billion yuan ($431 million) to attract users to its Qwen AI app during ​the Lunar New Year holiday, heating up a race between China's largest ‌tech firms.

The pledge by Alibaba, which triples the spending promised earlier by rivals Tencent and Baidu, is ‌set to start on February 6. It will involve incentives for dining, drinks, entertainment and leisure, with "large red envelopes distributed continuously," Alibaba said in a statement.

Tencent and Baidu announced late last month they would spend 1 billion yuan and 500 million yuan respectively on ⁠similar promotions for their AI ‌chatbots.

Chinese tech companies have long used the Lunar New Year festive period - when hundreds of millions travel home and spend time with ‍family - as a marketing battleground to acquire new users.

The most notable case was in 2015, when Tencent leveraged its WeChat messaging app to distribute digital red envelopes, helping its WeChat Pay service ​gain ground against Alipay, which then dominated China's mobile payments market.

The public holiday ‌period this year begins on February 15 and is nine days long, longer than in most previous years.

Competition in China's AI sector has accelerated since DeepSeek's R1 model launch in January last year rattled global AI markets, spurring both faster adoption and fiercer rivalry among domestic players.

Tencent's campaign focuses on its Yuanbao chatbot app and starts ⁠on Sunday. Users must upgrade the app to ​the latest version to claim digital red envelopes that ​can be withdrawn to their WeChat wallets. Users can also share links with cash rewards for others to claim.

Alibaba did not specify whether ‍rewards would be distributed ⁠as cash red envelopes or discount coupons redeemable on its platforms including e-commerce site Taobao.

Several other Chinese AI firms have also been releasing upgrades in ⁠the run-up to the holiday. DeepSeek is expected to launch its next-generation AI model V4, featuring strong ‌coding capabilities, in mid-February, The Information has reported.

($1 = 6.9519 yuan)

(Reporting by Liam Mo ‌and Brenda Goh; Editing by Stephen Coates)

Alibaba to spend $431 million for Lunar New Year AI push as chatbot war heats up

BEIJING, Feb 2 (Reuters) - Alibaba said on Monday it will spend 3 billion yuan ($431 million) to attract users to its Qwe...
Snack like a pro on Super Bowl Sunday with Panko-crusted chicken strips and game-changing sauce

Sometimes a chicken nugget is just a chicken nugget. Sometimes it's a crisp, panko-crusted strip of chicken breast with a sweet and tangy sauce. This is the latter.

Associated Press

Super Bowl Sundayis snack time at its finest. No one is looking for fancy footwork (at least not in the food realm; we do want to see that on the field). I have hosted more Super Bowl parties than I can (want to) count, and what I can tell you is that the delicate little canapes aren't going to fly off the buffet as fast as thenachos.

The best Super Bowl food lives in thesame realm as the best bar food. And that includes chicken tenders.

If you tend to think of chicken strips as a guilty, kiddie-centric pleasure, give yourself permission to relax and enjoy them. They're basically fried chicken sans bone.

But these chicken strips bake on a wire rack for maximum crispiness without frying. A little olive oil in the panko makes all the difference. For a spicy kick, add Sriracha to the egg wash.

Now the sauce, simple but game-changing: Melt apricot or orange preserves, stir inDijon mustardand fresh thyme, and dip away. It's sweet, tangy and herbaceous, perfect for dunking each golden strip.

Bake, sauce, serve. The platter disappears fast, so consider making a double batch for a larger crowd. Easy enough for a weeknight, special enough for the big game, and guaranteed to impress both kids and adults.

Crispy Chicken Strips with Apricot Mustard Dipping Sauce

Serves 4 to 6

Ingredients:

1/2 cup all-purpose flour

Kosher salt and freshly ground pepper to taste

2 large eggs

1/2 teaspoon Sriracha or other hot sauce, or to taste

1 1/2 cups Panko breadcrumbs

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2 tablespoons olive oil

1 1/2 pounds boneless, skinless chicken breasts, cut crosswise into 1-inch thick strips (or use chicken tenders)

1 cup apricot or orange preserves

3 tablespoons Dijon mustard

1/2 teaspoon minced fresh thyme leaves

Directions:

1. Preheat the oven to 400°F. Place a wire cooling rack into a rimmed baking sheet.

2. Place the flour, salt and pepper in a shallow bowl. Whisk together the eggs and Sriracha in a second shallow bowl. Combine the Panko and olive oil in a third bowl.

3. Working in small batches, toss the chicken strips in the flour, shake off any excess, dip them in the egg mixture, allow extra egg to drip back into the bowl, and roll them in the panko. Shake off any excess, then place the strips at least 1 inch apart on the wire rack. (It's possible you may need to bake these in two batches.)

4. Bake until the chicken strips are golden brown and cooked through, 15 to 18 minutes.

5. While the chicken is cooking, place the preserves in a small saucepan or skillet. Heat over low heat until melted, stirring occasionally, then stir in the mustard and thyme. Transfer the sauce to a small bowl, transfer the chicken strips to a serving platter and serve hot.

Katie Workman writes regularly about food for The Associated Press. She has written two cookbooks focused on family-friendly cooking, "Dinner Solved!" and "The Mom 100 Cookbook." She blogs athttps://themom100.com/.She can be reached at Katie@themom100.com.

For more AP food stories, go tohttps://apnews.com/hub/recipes

Snack like a pro on Super Bowl Sunday with Panko-crusted chicken strips and game-changing sauce

Sometimes a chicken nugget is just a chicken nugget. Sometimes it's a crisp, panko-crusted strip of chicken breast wi...
'Executions, torture, abductions, rape': Ethiopia's hidden conflict

Wanted by the Ethiopian government, rebel military leader Jaal Marroo moves constantly to stay ahead of drones hunting him from the skies.

The rebel commander leads the Oromo Liberation Army (OLA) from a series of remote forest outpost in Oromia, the country's biggest region with a population of roughly 40 million people.

The government has designated the former student as a terrorist, accusing the OLA of massacring civilians in ethnically motivated attacks. But in a rare interview from one of his hideouts, Marroo rejected accusations that his fighters target civilians.

"Our war is not against the people," he told The Associated Press. "It is against the brutal regime that has occupied and oppressed the nation for generations."

He added: "We are fighting to correct a system that treats the Oromo as subjects, rather than citizens. Our goal is to establish a democratic, inclusive political order based on the will of the people."

'Almost impossible to travel'

The OLA has beenbattling Ethiopia's governmentsince 2018, even if at times the rebellion was overshadowed by the country's other conflicts, such as the 2020-2022 war in the northernTigray region. United Nations investigators have accused the OLA of serious abuses, including killings, rapes and kidnappings.

But human rights monitors, who have also documented violations by government forces, say indiscriminatedrone strikes, extrajudicial killings and disappearances have become a hallmark of their counterinsurgency campaign.

"The research that we conducted puts both the OLA and the government forces in the middle of the conflict in terms of summary executions, in terms of torture, in terms of abductions, in terms of rape of women," said Sarah Kimani, a regional spokesperson for Amnesty International, which will publish a report in March into human rights abuses in the region.

"Our report is able to point to both groups having been responsible for the atrocities that are being carried out in the Oromia region and that continue to be carried out against civilians in the region," she told the AP.

Ayantu Bulcha was at home in the capital,Addis Ababa, when she heard that soldiers had come to her family's house in Oromia in early December. Her cousin was shot outside the property, she said. Then the soldiers took her father and her uncle to a nearby field, where they were also killed, she said. They had been accused of fighting alongside the OLA.

"There have been threats against my family since the killing, and even before that," said Bulcha, who is a member of an Ethiopian opposition party. She denies allegations that her relatives belonged to the rebels.

Lensa Hordofa, a civil servant from Oromia's Shewa region, said her family faces constant harassment and extortion from armed men. This includes demands for food and other supplies. Her uncle was recently detained and only released after paying a ransom of 100,000 Ethiopian birr ($650).

"Movement from place to place has become increasingly restricted," she said. "It's almost impossible to travel."

Bulcha said she was too scared to return home, fearing retaliation by government forces.

"My frail mother is left alone in an empty house, grieving. I can't even go there to grieve with her," she said. "

Attacks on hospitals and clinics

Ethiopiarestricts access to Oromia for journalists and rights groups, meaning the conflict is largely hidden.

"Unfortunately, the human rights situation — as well as the overall humanitarian crisis in Oromia — is underreported," said Getu Saketa Roro, co-founder of Human Rights League of the Horn of Africa. .

Regional and federal government representatives did not respond to requests for comment.

In January 2025, the U.N. reported that 3.2 million children were not in school because of the fighting. In theWollega district, where Bulcha's family lives, aid groups struggle to distribute supplies, contributing to high malnutrition.

Hospitals and clinics have also come under attack. In 2023, the International Committee of the Red Cross reported that "nearly all" the 42 health posts in Oromia's Begi district had been looted or damaged.

Tulu Getachew, a coffee farmer from Wollega, has been unable to return home for three years due to the security situation. He hired workers to collect his beans, but the harvest was stolen by armed men.

''One party hurts you because they say you belong to the other," he said. "You suffer because they say your family member is affiliated with the government or OLA."

Although Ethiopia's Prime MinisterAbiy Ahmedis from Oromia — and the Oromo make up roughly 35% of Ethiopia's population — many Oromo say that they are still marginalized in Ethiopia's federal system, which grants resources and self-governance rights based on ethnicity.

'Oromia is very insecure'

Recent government offensives have eroded the OLA's military capabilities, analysts say. At the end of 2024 the authorities convinced one of the group's main commanders to defect, further degrading its capabilities.

The government claims hundreds of thousands of displaced people have been able to return home. But the conflict continues to destabilise the region, with civilians caught in the middle of the violence.

Members of theAmhara ethnicity, Ethiopia's second-biggest group, have been targeted for attacks, according to rights monitors. Meanwhile insurgents from the region of Amhara have also carried out attacks in Oromia.

Armed banditry is also prevalent, and kidnapping has become a particular issue. It is not always clear who is responsible for the abductions.

"Oromia is very insecure, not simply because of the OLA but because of other groups operating as criminal enterprises, engaging in extortion, kidnapping and robberies," said Magnus Taylor, Horn of Africa director at the International Crisis Group.

For more on Africa and development:https://apnews.com/hub/africa-pulse

The Associated Press receives financial support for global health and development coverage in Africa from the Gates Foundation. The AP is solely responsible for all content. Find AP'sstandardsfor working with philanthropies, a list of supporters and funded coverage areas atAP.org.

'Executions, torture, abductions, rape': Ethiopia’s hidden conflict

Wanted by the Ethiopian government, rebel military leader Jaal Marroo moves constantly to stay ahead of drones hunting hi...
A mix of hope and fear settles over Venezuela after US-imposed government change

CARACAS, Venezuela (AP) — Time in Venezuela feels like it's moving both too fast and too slow. The pillars of the country's self-proclaimed socialist government are falling at a dizzying pace or not quickly enough. Economic relief is finally on the horizon or already too late.

Thirty days after the U.S.raid and capture of then-President Nicolás Maduroupended Venezuela, adults and children alike are still unsure of what exactly is happening around them. And as the initial shock gives way to a mix of uncertainty, hope and disappointment, a pervasive fear of another attack or more government repression continues to hang over them.

In the capital,Caracas, where government-sponsored billboards and graffiti demand that the U.S. free Maduro, many residents wonder whether his successor,acting President Delcy Rodríguezhas any autonomy or is capitulating to White House demands; whether she is Maduro by another name, and — crucial to their immediate needs — whether to believe, as indicated by her, that a long-sought wage increase is on the horizon. Meanwhile, long-silent opposition leaders have finally emerged to speak publicly.

"It's an important change, certainly, but everything is the same, everything," retiree Julio Castillo, 74, said of the removal of Maduro from office. "I feel as if nothing much has happened."

'We are acting under coercion'

Venezuela's government and its supporters consider the capture of Maduro and first lady Cilia Flores a kidnapping. Rodríguez and senior officials have pledged to fight for the couple's freedom sinceU.S. President Donald Trumpfirst announced their seizure in the early hours of Jan. 3.

The ruling party has organized demonstrations to show their loyalty to Maduro, whom the fiery Hugo Chávez anointed as his self-proclaimed socialist revolution's torchbearer before dying in 2013. It has also adjusted its messaging from threatening a Vietnam-like war with the U.S. to admitting being militarily outmatched and needing to transform the relationship with Goliath.

Supporters — a minority compared to the crowds during Chávez's presidency — see Rodríguez as lacking free will but trust that she can carry Chavismo, their political movement, through the next diplomatic battle.

"The Venezuelan state, and Venezuelans, are accepting this new situation in which we are acting under coercion," José Vivens, a Maduro loyalist, said of Rodríguez's decision to allow the Trump administrationto control Venezuela's oil money, the country's engine. "They kidnapped our commander. And we have to give in because we have to live for another battle."

Vivens, a justice of the peace, was in his apartment's parking lot in Caracas when he heard a loud whistle, then a deafening explosionthe night of the attack. He ducked behind his car, and when he looked up, helicopters were flying unnervingly close to his building.

"They've invaded us," was Vivens' immediate thought. Not exactly, but he would learn a few hours later that the U.S. military's elitehad captured Maduro at a nearby compoundand loaded him onto a helicopter.

Abandoning a pillar of Chavismo

Rodríguez has used public events and gatherings with Venezuela's private sector to assure anyone listening that she, not the Trump administration, is governing the South American country, even if she later acknowledges having a mutual agenda with the U.S., which was unthinkable weeks earlier.

"The people of Venezuela do not accept orders from any external factor," she said during a meeting with oil executives to discuss an overhaul of the country's energy law. "The people of Venezuela have a government, and this government obeys the people."

Her proposed overhaul, which lawmakers swiftly approved and she signed into law Thursday, opens thenation's oil sectorto privatization, abandoning a pillar of Chavismo.

She introduced it following Trump's assertion that his administration wouldtake controlof Venezuela's oil exports andrevitalize the ailing industrybyluring foreign investment.

Testing the waters

Many within the opposition had long expected that Maduro's ouster, especially if led by Trump, would immediately result in one of their own taking the reins of the country. Trump's decision to work with Rodríguez, instead ofopposition leader and Nobel Peace Prize laureate María Corina Machado, continues to leave them baffled.

But as Machado's supporters keep looking for signs that the White House will incorporate her meaningfully into its plans for their country, Venezuelans have begun testing Rodríguez's commitment to what she has called "a new political moment" for Venezuela.

For days, dozens of peoplehave kept vigil outside prisonsdemanding the release of loved ones they believe were detained for political reasons, including journalists, human rights advocates and members of the military. A handful of opposition leaders who had not been seen in public in Venezuela or made any statements for more than a year have spoken out.

"I believe that Venezuela's destiny cannot be an oil agreement and a dictatorship headed by Delcy Rodríguez, because we could simply define that as a continuation of the dictatorship," opposition leader Andrés Velásquez told reporters, reemerging after more than a year in hiding.

A privately owned television channel with national reach on Wednesday even aired a clip of Machado addressing reporters in Washington. Neither public nor private media outlets had shown a similar segment in years.

Still, many Venezuelans continue to self-censor as they remain deeply fearful ofgovernment repression. Their social media posts make no mention of politics. Written or audio messages on WhatsApp do not criticize the government. Some video calls involve writing and erasing information on whiteboards as an extra layer of protection.

There have been no large demonstrations calling for a new government or a presidential election. Nor has anyone dared to publicly celebrate Maduro's capture — even if many had long hoped to see him handcuffed.

Many opposition leaders remain in exile. Wanted posters ofEdmundo González, the opposition's candidate during the 2024 presidential election, are still on display at airports and government offices.

Balancing hope and fear

Margaret García's son could not sleep for days after Jan.3. He also did not want to go back to school fearful of not knowing what to do if another attack happened.

"We thought we were going to die," she said of the moment her family heard a helicopter open fire near their 15-story apartment building near where Maduro was captured.

Her son's fear was far from unique. Some Venezuelans still fear a second attack if Rodríguez's government does not meet U.S. expectations — even as Washington has indicated it has no plans for further escalation.

"I can tell you right now with full certainty, we are not postured to nor do we intend or expect to have to take any military action in Venezuela at any time," U.S. Secretary of State Marco Rubio told a U.S. Senate committee on Wednesday.

García, a teacher, said she could not understand how anyone could find satisfaction in the U.S. operation thatkilled dozens. Still, she said she believes that under Rodríguez's watch, the country could see the lasting economic improvements that workers have hoped for more than a decade.

Like García, many public sector workerssurvive on roughly $160 per month, while the average private sector employee earned about $237 a month last year. Venezuela's monthly minimum wage of 130 bolivars, or $0.35, has not increased since 2022, putting it well below the United Nations' measure of extreme poverty of $2.15 a day.

"We see that a negative moment has brought us positive things," she said of the potential changes that Rodríguez has signaled will come with an envisioned oil boom.

Follow AP's coverage of Latin America and the Caribbean athttps://apnews.com/hub/latin-america

A mix of hope and fear settles over Venezuela after US-imposed government change

CARACAS, Venezuela (AP) — Time in Venezuela feels like it's moving both too fast and too slow. The pillars of the cou...

 

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